Originally shared on the public FactorioPrints / Factorio School archive (factorioprints.com · factorio.school). Authorship preserved from the public catalog.
OVERVIEW
This set of science blueprints is designed with game progression in mind. It will scale with the player's tech and always be a natural progression, never outpacing what the player has available to them at any stage in the game.
While intended to be used as a set, blueprints can be used individually--see the input markers on the Factorissimo blueprints themselves. Each unstacking beltbox is filtered to prevent the wrong resource from flooding the system.
Minimal resources are required as inputs; intermediate resources such as Sulfuric Acid, Plastic, Stone Brick, etc. are created onsite to reduce the number of inputs required.
Resource consumption efficiency (productivity) is not considered until white beakers. When you finish with the six other beaker types, destroy everything and use the bot farm blueprint instead, which maximizes resource productivity and assumes that you already have an extensive production network in place.
In total, this system provides 1.5 beakers/second of each type until the white beaker bot farm, which varies depending on what modules you have.
These blueprints feature multiple aesthetic and quality-of-life enhancements, including: linking inserters, rate-limiting outputs, grid-snapping, filtered unboxing (to prevent flooding a blueprint with the wrong material by accident), providing precisely the correct-color assemblers (where possible), and combinator markers for all inputs.
RED/GREEN
Resources required: copper, iron.
"Early Red/Green" is provided as an outdoors standalone blueprint to allow players to establish limited research early on, then switch to a Factorissimo/Beltbox setup once other base infrastructure has been created.
Even if you hold off and opt not to use the outdoor "Early Red/Green", you must research Automation 2 (green beakers required) and Stacking 1 (beltboxes) before you can place the Red/Green Factorissimo blueprint.
Research Lab Research Speed 2 as soon as possible. You'll need it at level 2 before 30 labs can process 1.5 beakers per second for 30 second research projects. (Shorter research projects will exhaust beakers much quicker.)
Make sure to research Inserter Capacity Bonus 2 before moving on to blue/black, because future blueprints will rely on inserters moving more than one object at a time.
Blue is designed to be crude-oil-fed at first, assuming you do not have a petroleum gas infrastructure in place when you start blue beakers. Once you begin generating petroleum gas offsite, you may wish to disconnect the crude oil and connect the petroleum gas pipeline instead.
After you get up to Lab Research Speed 4, insert Productivity modules into all of the labs. (The best modules you have.) The extra speed from the research will offset the modules and you'll get more bang out of your materials.
YELLOW/PURPLE
Additional resources required: steel, red circuits, green circuits, lubricant.
You are assumed to be doing purple beakers first to get Automation 3 since those assemblers are used for yellow beakers.
You will need to turn up the input power into the yellow beaker factory from 20 MW to 50 MW for it to run at full speed (shift-R on the yellow arrow by the door).
WHITE
Additional resources required: light oil.
Destroy everything and set up a new base blueprint, you can use the same location (same inputs). This base is designed to accommodate multiple large Factorissimos, each of which is a self-enclosed bot-based blueprint. The base can also be scaled--copy on the stone markings to tile up or tile to the right.
The bot-based blueprint itself is designed as a tier 3 module blueprint but filled with tier 1 modules. This is so that you can place one as you just hit white research and then upgrade it once you have the modules to do so later (using an upgrade planner specifically for modules).
If you partially upgrade the modules, focus on putting better production modules in the rocket ship and the expensive beakers (purple, yellow) first.
The blueprint produces 0.875 beakers/sec at tier 1 and 2.52 beakers/sec at tier 3. If you have the materials to spare (especially steel), you should prefer to build more research facilities with lower-tier modules rather than focus on high-tier modules.
Final consumption numbers for 2.520 beakers/sec: 324.6 MW energy, 28.6 iron, 64.2 copper, 34.0 stone, 14.3 coal, 24.6 steel, 56.1 green circuits, 19.0 red circuits, 153.8 petroleum gas, 119.6 light oil, 4.6 lubricant, and water.