My solution for end game science to use my legendary modules, work with normal T3 modules at reduce rate. Produce about 10k/m of Agriculture Science . +/- 400 dépending of the orientation. And the roquets need to send them to space. You gonna need at least 4 pumps for water, Require manual input of the first pentapod egg, a stack of uranium fuel cell, and a few nutrients Tested for 10+ hours, without a single issue.
Inspired by AbsoCZ : https://www.factorio.school/view/-OBSabLpqu-pMQbWkKcy