Originally shared on the public FactorioPrints / Factorio School archive (factorioprints.com · factorio.school). Authorship preserved from the public catalog.
I created this blueprint because I wanted to get rid of the huge amount of Uranium-238 I was producing, but I could only find overly complicated solutions. This one is simple and maybe not the most efficient, but so far, it's been working well.
Just feed it with an initial amount of Uranium-235 (40 pieces), and then continuously supply it with Uranium-238.