This ship is able to reach Aquilo with max. bullet and explosion upgrades (without endless research) without taking damage. Only little downtime to restock rockets is needed.
It takes some time to get started. Especially to get enough water for the nuclear reactor and for a stockpile of asteroids for continuous production. After that it takes only a little bit of nuclear fuel to maintain everything. Tip: After the first startup fly between inner planets to get more asteroids to fill the storage up.